Mark T Bedford Selected Research

coactivator-associated arginine methyltransferase 1

12/2020	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.
1/2019	Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
1/2018	The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis.
12/2015	Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility.
5/2013	A TR-FRET-based functional assay for screening activators of CARM1.
7/2011	Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.
7/2010	CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
1/2007	The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.
9/2006	Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene.

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Mark T Bedford Research Topics

Disease

28	Neoplasms (Cancer) 01/2022 - 11/2002
9	Breast Neoplasms (Breast Cancer) 01/2019 - 09/2006
3	Retinoblastoma (Glioblastoma, Retinal) 10/2019 - 08/2014
3	Inflammation (Inflammations) 01/2011 - 01/2005
2	COVID-19 01/2021 - 12/2020
2	Herpes Zoster 01/2021 - 12/2020
2	Pneumonia (Pneumonitis) 01/2021 - 12/2020
2	Dengue (Dengue Fever) 10/2020 - 03/2020
2	Carcinogenesis 01/2019 - 12/2015
2	Fever (Fevers) 07/2018 - 10/2017
2	Prostatic Neoplasms (Prostate Cancer) 03/2016 - 07/2010
2	Brain Neoplasms (Brain Tumor) 03/2014 - 03/2013
2	Neoplasm Metastasis (Metastasis) 12/2013 - 02/2011
2	Leukemia 04/2011 - 04/2008
2	Tuberous Sclerosis (Bourneville's Disease) 05/2010 - 11/2002
1	Glioma (Gliomas) 07/2022
1	Infections 12/2021
1	Lymphoma (Lymphomas) 12/2020
1	Lung Neoplasms (Lung Cancer) 01/2020
1	Oligospermia (Oligozoospermia) 01/2018
1	Male Infertility (Male Sterility) 01/2018
1	Triple Negative Breast Neoplasms 01/2018
1	Genomic Instability 08/2016
1	Emphysema 12/2015
1	Multiple Sclerosis 07/2011
1	Rheumatoid Arthritis 07/2011
1	Adenocarcinoma 07/2010
1	Chromosome Aberrations (Chromosome Abnormalities) 08/2008
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2007

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2004
10	ChromatinIBA 07/2022 - 08/2008
9	coactivator-associated arginine methyltransferase 1IBA 12/2020 - 09/2006
8	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 08/2008
7	Histones (Histone)IBA 10/2020 - 04/2011
6	MethyltransferasesIBA 07/2022 - 04/2011
6	RNA (Ribonucleic Acid)IBA 07/2022 - 12/2015
5	Arginine (L-Arginine)FDA Link 01/2020 - 01/2013
4	Lysine (L-Lysine)FDA Link 01/2018 - 03/2014
3	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 10/2020 - 12/2013
3	Biological ProductsIBA 01/2018 - 06/2004
2	Messenger RNA (mRNA)IBA 01/2022 - 09/2006
2	ChloridesIBA 01/2021 - 12/2020
2	Peptides (Polypeptides)IBA 01/2021 - 12/2020
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 10/2020 - 03/2020
2	TransferasesIBA 01/2020 - 12/2015
2	Carrier Proteins (Binding Protein)IBA 01/2020 - 02/2011
2	Tamoxifen FDA LinkGeneric 01/2020 - 01/2011
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 10/2019 - 08/2014
2	human PRMT2 proteinIBA 12/2017 - 06/2011
2	Protein Isoforms (Isoforms)IBA 03/2016 - 07/2011
2	Estrogen ReceptorsIBA 05/2013 - 01/2011
2	EnzymesIBA 01/2013 - 01/2007
2	Hormones (Hormone)IBA 07/2011 - 06/2011
2	Tuberous Sclerosis Complex 2 ProteinIBA 05/2010 - 11/2002
2	NF-kappa B (NF-kB)IBA 03/2008 - 01/2005
1	Long Noncoding RNAIBA 07/2022
1	Programmed Cell Death 1 ReceptorIBA 01/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022
1	CytokinesIBA 01/2022
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 12/2020
1	Biomarkers (Surrogate Marker)IBA 12/2020
1	UbiquitinIBA 10/2020
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2020
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 10/2020
1	InterleukinsIBA 01/2020
1	Urethane (Ethyl Carbamate)IBA 01/2020
1	CarcinogensIBA 01/2020
1	Recombinases (Recombinase)IBA 01/2019
1	Keratins (Keratin)IBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2018
1	AnionsIBA 01/2018
1	Ligases (Synthetase)IBA 10/2017
1	TubulinIBA 08/2016
1	UNC3866IBA 03/2016
1	Pancreatic Elastase (Elastase)IBA 12/2015
1	UNC1215IBA 03/2013
1	Transcription Factors (Transcription Factor)IBA 07/2012
1	Tyrosine (L-Tyrosine)FDA Link 01/2012
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2012
1	Nuclear Antigens (Extractable Nuclear Antigens)IBA 01/2012
1	Oncogene Proteins (Oncogene Protein)IBA 04/2011
1	borrelidinIBA 02/2011
1	PolyketidesIBA 02/2011
1	ForminsIBA 02/2011
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 08/2008
1	sirtinolIBA 04/2008
1	CurcuminIBA 04/2008
1	Eosine Yellowish-(YS) (Eosin)IBA 04/2008
1	RNA Splicing FactorsIBA 01/2007
1	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2002
1	PhosphoproteinsIBA 11/2002

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2016